Pharmacological comparison of four biopolymeric natural gums as hemostatic agents for management of bleeding wounds: preliminary in vitro and in vivo results

Abstract Background Uncontrolled bleeding is one of the primary reasons for preventable death in both civilian trauma and military battle field. This study evaluates vitro vivo hemostatic potential four biopolymeric natural gums, namely, gum tragacanth, guar gum, xanthan acacia. In evaluation whole blood clotting time erythrocyte agglutination assay were carried out. cytotoxicity studies with respect to each done human lymphocytes ascertain percent cell viability. (as sponge dressing powder form) was evaluated Sprague Dawley rats using tail compared commercially available sponge. Other important parameters like (a) taken complete hemostasis, (b) amount absorbed, (c) adherence strength developed dressing(s), (d) incidence re-bleeding, (e) survival animals also studied. Results Of test gums studied, (@3mg/ml blood) tragacanth (@35mg/ml able clot least (58.75±6.408 s 59.00±2.082 s, respectively) exhibited very good . Except all other did not exhibit any significant at different points till 24 h. rat experiments, achieved hemostasis (156.2±12.86 76±12.55 much earlier than product (333.3±38.84 s; p ˂0.01). Conclusion indicate be into a suitable product.